Video Interview

Cognitive function and decline in pre-diabetes/IH and T2D

Roxana V. Ahrițculesei, Romania

10 November 2026

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Overview

The link between cognitive dysfunction (e.g. visuospatial functions, naming, language, learning and memory performance [Şen, 2024; Sumbul-Sekerci, 2025]) and T2D, caused by central neuropathy has been understood for some time but is not well known [Sjöholm, 2025]. Recent research looking into the pathogenic factors causing cognitive impairment in T2D have focussed on cerebral insulin resistance, defective insulin signalling, inflammation, oxidative stress, endothelial dysfunction and neuropathology [Sjöholm, 2025; Sumbul-Sekerci, 2025]. Cognitive function may be affected in women with a history of GDM [Soria-Contreras, 2025] and significant impairments in attention and memory that affect daily life have been associated with PCOS [Pinto, 2024]. Both IH and T2D are associated with accelerated cognitive decline, especially in people with poor cardiometabolic health or hypertension [Dove, 2024; Santulli, 2024]. Several pharmaceutical therapies for T2D, have shown promising results in improving cognition in people with T2D [Sjöholm, 2025] e.g. reports of metformin improving memory and reducing the risk of neurodegenerative diseases [Enderami, 2025; Santulli, 2024].

Learning Objectives

At the end of the activity, learners should be able to:

  • • Have knowledge of the decline in cognitive function that can occur in people with IH or T2D
  • • Recognise the additional risk factors for accelerated cognitive decline in people with IH or T2D

Target Audience

HCPs managing patients with T2D including clinicians involved in endocrinology, particularly diabetes, pre-diabetes/IH; obesity management and general practice; some content of interest to vascular specialists and cardiologists

Language

English with voice over into Spanish and Chinese

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Cognitive function and decline in pre-diabetes/IH and T2D

Launch 10 November 2026

Faculty

Roxana Viorela Ahrițculesei

Roxana Viorela Ahrițculesei

Specialist in Diabetes, Nutrition and Metabolic Diseases
Filantropia Clinical Municipal Hospital
Craiova, Romania
Biography

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FUNDING

· Martin O. Savage ·

Martin Savage is Emeritus Professor of Paediatric Endocrinology at William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary, University of London. He was head of the Paediatric Endocrine Unit at Barts and the London School of Medicine from 1982 to 2007. He has interests in growth disorders, specifically those with abnormalities in the GH-IGF-1 axis and in phenotype-genotype relationships of GH-IGF-1 axis defects, notably GH resistance. He published the first human case of an IGF-1 gene defect in the New England Journal of Medicine in 1996.  His other interests are Cushing’s syndrome and growth in chronic inflammatory diseases. He was General Secretary of the European Society for Paediatric Endocrinology (ESPE) from 1997 to 2004. He has lectured in 60 countries and has published 482 original articles, reviews, textbook chapters and books. In 2007, he was awarded the ESPE Andrea Prader Prize for contributions to paediatric endocrinology and in 2018 he received a Visionary Award from the American Human Growth Foundation. In 2022, he received a Research Excellence Award from the Dr Sulaiman Al Habib Medical Journal in Riyadh, and the British Society of Paediatric Endocrinology & Diabetes James M. Tanner Lifetime Achievement Award. He continues to lecture nationally and internationally.

· Roxana V. Ahrițculesei ·

Roxana Viorela Ahrițculesei, MD, is a Specialist in Diabetes, Nutrition and Metabolic Diseases and a Resident Physician in Endocrinology at Filantropia Clinical Municipal Hospital in Craiova, Romania. She combines clinical practice with academic research, providing specialist care for people with prediabetes, type 2 diabetes, obesity and other metabolic disorders. Her doctoral research investigates the interplay between inflammation, neurotransmitters and metabolic disease, with particular emphasis on the biological mechanisms linking dysglycaemia to cognitive dysfunction. Her work also reflects a strong interest in prevention, early risk identification and the timely management of metabolic complications. Dr. Ahrițculesei has authored and co-authored multiple peer-reviewed publications in international journals, including the International Journal of Molecular Sciences, Diagnostics, Nutrients and Life. Her scientific work has explored inflammatory biomarkers, neurotransmitter alterations and obesity-related metabolic risk in people with prediabetes and newly diagnosed type 2 diabetes. She is a member of the Romanian Society of Diabetes, Nutrition and Metabolic Diseases, the Romanian Association for the Study of Obesity (ARSO), the European Society for Clinical Nutrition and Metabolism (ESPEN), and the Physicians Association for Nutrition (PAN). She is committed to advancing evidence-based, patient-centred prevention and care.

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