4th Male Infertility Educational Activity

APHRODITE criteria for male infertility diagnosis, prognosis and management

1st Live ANDROFERT - 14 March 2025
2nd Live Skive Fertility Clinic - 11 April 2025
3rd Live University Hospitals Leuven - 3 October 2025

ON DEMAND SESSIONS Educational Materials
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On demand Session
14 March

On demand Session
11 April

On demand Session
3 October

APHRODITE criteria for male infertility diagnosis, prognosis and management

Continuing Medical Education (CME)

14 March - 11 April - 3 october 2025

Overview

Key information exploring male infertility and utilizing the APHRODITE criteria would be presented in preceptorship format, involving pre-recorded video lectures and local case presentations (given live). Andrology, the branch of medicine concerned with male sexual and reproductive health, emerged as a specialty at the end of the nineteenth century. However, only in the latter half of the past century was andrology recognized as one of the most intriguing sub-specialties of human reproduction. The demand for andrologists and reproductive urologists is increasing but there are insufficient experts to keep pace with requirements. The scope of modern andrology covers a broad spectrum, from genetic studies to assisted reproduction techniques, and there is a clear need to update healthcare professionals in these aspects. This preceptorship will offer urologists, gynecologists, embryologists, andrologists and scientists working in ART opportunities to learn the tools to implement reproductive andrology in a fertility center. Participants will be guided by international experts through lectures, debates and interactive discussions. Apart from providing new insights into male infertility, this educational activity will guide a live journey through a modern centre specializing in male reproductive health. The virtual preceptorship features pre-recorded lectures that will be released before live sessions (practical sessions in three ‘host’ clinics). In their own time, participants will view the video lectures, review recommended literature, and complete MCQs (which are set as part of the online video lectures) before the live session. Each live session provides practical, in-depth learning and will engage a group of participants who have prepared locally relevant case studies and questions. The selected case studies/questions are presented to the whole group and discussed by the host Clinic team. During the preceptorship, users will be able to visit the chatroom to discuss and debate topics relevant to the optimal clinical management of each case.

Key aims

  • ● For clinicians to understand and apply the best principles of male infertility diagnosis/assessment
  • ● For clinicians to implement relevant, individualized, and effective treatment protocols in a greater proportion of subfertile and infertile men than was previously possible, using APHRODITE criteria

Learning Objectives

After participating in both webinars, attendees will be able to:

  • ● Characterize the role of gonadotropins in spermatogenesis
  • ● Characterise the role of LH in spermatogenesis
  • ● Stratify patients with infertility according to the APHRODITE criteria
  • ● Based on APHRODITE criteria and guidance, identify potential management strategies for men with the most common causes of male infertility

Target Audience

The program is intended for clinicians, embryologists, andrologists, scientists, and managers working in MAR who wish to update their knowledge of advanced techniques and scientific innovations and understand best practices using evidence-based models of care.

European Accreditation Council for Continuing Medical Education Accreditation

The 4th Male Infertility Educational Activity APHRODITE criteria for male infertility diagnosis, prognosis and management, Virtual, Italy, 03/10/2025 – 03/10/2025, has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) with 2.0 European CME credits (ECMEC®s).

Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.

Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at https://edhub.ama-assn.org/pages/applications .

“Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.

Information regarding the conversion of EACCME® credits
Credit will be converted based on one (1) hour of participation equalling one credit for all activities. Physicians wishing to convert EACCME® credits to AMA PRA Category 1 Credit™ will be required to access the AMA website at https://edhub.amaassn.org/pages/applications to obtain the necessary paperwork and instructions. Physicians and other health care professionals will be required to pay a processing fee to the AMA. For other countries, please contact the relevant national/regional accreditation authority.

uems-eaccme-logo

The preceptorship will be in partnership with three proposed centers:

14 March 2025 – Androfert – Andrology and Human Reproduction Clinic (Campinas, Brazil)

11 April 2025- Skive Fertility Clinic, Faculty of Health. Aarhus University, Denmark

3 October 2025 – University Hospitals Leuven, Belgium

The programme has been developed in partnership with

Addressing male Patients with Hypogonadism and/or infeRtility Owing to altereD Idiopathic TEsticular function (APHRODITE)

Patient Oriented Strategies Encompassing IndividualizeD Oocyte Number (POSEIDON)

Med.E.A. is in partnership with

Algerian Society of Reproductive Medicine (SAMERE)

Association of Reproductive Medicine and Surgery (ARMS)

British Fertility Society (BFS)

Brazilian Society of Human Reproduction (SBRH)

Italian Society of Embryology, Reproduction and Research (SIERR)

Italian Society of Fertility and Sterility (SIFES)

Italian Society of Gynecology and Obstetrics (SIGO Federation)

Portuguese Society of Reproductive Medicine (SPMR)

Turkish Society of Reproductive Medicine (TSRM)

Agenda

Faculty

Leen Antonio

Leen Antonio

Clinical and Experimental Endocrinology
Leuven, Belgium
Biography
Sandro C. Esteves

Sandro C. Esteves

Androfert – Andrology and Human Reproduction Clinic
Campinas, Brazil
Biography
Peter Humaidan

Peter Humaidan

Fertility Clinic, Skive Regional Hospital
Faculty of Health, Aarhus University
Aarhus, Denmark
Biography

International Committee

Paola Anserini

Paola Anserini

UOS Fisiopatologia della Riproduzione Umana (FRU)
Ospedale Policlinico San Martino
Genova, Italy
Biography
Baris Ata

Baris Ata

ART Fertility Center
Koc University Istanbul
Dubai, United Arab Emirates
Biography
Luís F. Vicente

Luís F. Vicente

Portuguese Society of Reproductive Medicine
Portugal
Biography
Kevin McEleny

Kevin McEleny

Queen Elizabeth Hospital
Gateshead and the Freeman Hospital
Newcastle, UK
Biography
Paula Navarro

Paula Navarro

Ribeirão Preto Medical School
University of Sao Paulo,
Sao Paulo, Brazil
Biography
Amina Oumeziane

Amina Oumeziane

Tiziri IVF Center
Algiers, Algeria
Biography
Emre Pabuçcu

Emre Pabuçcu

Ufuk University School of Medicine
Ankara, Turkey
Biography
Valerio Pisaturo

Valerio Pisaturo

Laboratory Director at Policlinico Umberto I
Rome, Italy
Biography

Scientific Programme and
Educational Materials

Final Programme

Video lectures

Open-access
Library

Pre-event materials

L1 Biology of spermatogenesis and pathophysiology of infertility and hypogonadism
Leen Antonio, Belgium
 
L2 Gonadotropin therapy in male infertility management: an overview
Peter Humaidan, Denmark
 
L3 Introduction to APHRODITE: rationale and group classification
Sandro Esteves, Brazil

Agenda

· Martin O. Savage ·

Martin Savage is Emeritus Professor of Paediatric Endocrinology at William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary, University of London. He was head of the Paediatric Endocrine Unit at Barts and the London School of Medicine from 1982 to 2007. He has interests in growth disorders, specifically those with abnormalities in the GH-IGF-1 axis and in phenotype-genotype relationships of GH-IGF-1 axis defects, notably GH resistance. He published the first human case of an IGF-1 gene defect in the New England Journal of Medicine in 1996.  His other interests are Cushing’s syndrome and growth in chronic inflammatory diseases. He was General Secretary of the European Society for Paediatric Endocrinology (ESPE) from 1997 to 2004. He has lectured in 60 countries and has published 482 original articles, reviews, textbook chapters and books. In 2007, he was awarded the ESPE Andrea Prader Prize for contributions to paediatric endocrinology and in 2018 he received a Visionary Award from the American Human Growth Foundation. In 2022, he received a Research Excellence Award from the Dr Sulaiman Al Habib Medical Journal in Riyadh, and the British Society of Paediatric Endocrinology & Diabetes James M. Tanner Lifetime Achievement Award. He continues to lecture nationally and internationally.

· Leen Antonio ·

Prof. Dr. Leen Antonio, MD PhD, is a medical specialist in Endocrinology and Diabetes. She works as endocrinologist and andrologist at the department of Endocrinology of the University Hospitals Leuven, Belgium and as an assistant professor at the Department of Chronic Disease and Metabolism of the Faculty of Medicine, KULeuven, Belgium. As a clinician-scientist, her areas of expertise (clinical as well as research research) include andrology, reproductive endocrinology, male infertility, and steroid hormone measurements.

She holds the Clinical Andrologist Certificate from the European Academy of Andrology. She is a member of the guideline committee and male health awareness committee of the European Academy of Andrology and working group leader in COST action ANDRONET. She is associate editor for the Journal of Sexual Medicine.

· Sandro C. Esteves ·

Sandro C. Esteves, MD., PhD. is a reproductive urologist who specializes in treating male infertility, particularly its connection with assisted reproductive technology (ART). He is the founder and medical director of ANDROFERT, a fertility center based in Campinas, Brazil, dedicated to male reproductive health. He is also a Collaborating Professor of Urology at the University of Campinas (UNICAMP), Brazil, and an Honorary Professor of Reproductive Medicine at Aarhus University, Denmark.

Dr. Esteves earned his medical degree in 1990 from the Faculty of Medical Sciences at UNICAMP, where he also completed his urology residency. He pursued a research fellowship at the Cleveland Clinic Foundation in the United States, focusing on male infertility. He later obtained a master’s degree in Surgery from UNICAMP and a PhD in Urology from the Federal University of São Paulo (EPM–UNIFESP). With more than 25 years of experience, Dr. Esteves has significantly advanced our understanding of male infertility in both clinical and academic settings. His work has focused on sperm DNA fragmentation, the importance of accurate semen analysis, and the limitations of basic diagnostics. He has underscored the role of varicocele repair and hormonal therapy in improving male fertility, particularly in non-obstructive azoospermia. He is the lead author of the APHRODITE criteria, a novel classification system designed to guide the treatment of men with testicular dysfunction and improve fertility outcomes through personalized hormonal therapy.

Dr. Esteves is a prolific author with over 350 published scientific papers, as well as numerous book chapters, and textbooks. He holds a Hirsch index of 78 and has been cited over 20,ooo times. According to the Science-Wide Author Databases of Standard Citation Indicators (Elsevier/Stanford), he is ranked among the top 1% of global researchers. He is a founding member of the POSEIDON group, which developed new stratification criteria for couples with a low prognosis undergoing ART. In addition to his clinical work and research, Dr. Esteves serves as Associate Editor/Section Editor for several journals, including Human Reproduction, Andrology, Reproductive Biomedicine Online, Frontiers in Endocrinology, and the International Brazilian Journal of Urology. He is also an editorial board member of many journals, including Nature Reviews Urology and International Urology and Nephrology. At ANDROFERT, Dr. Esteves has led initiatives to implement cleanroom technologies and quality management systems (ISO 9001), achieving national recognition for excellence in male fertility care. His team has consistently delivered outstanding results in treating complex cases of male infertility. A frequent speaker at national and international conferences, Dr. Esteves has received numerous research grants and awards. He serves as the head of the Andrology Committee at the Brazilian Society of Human Reproduction and is the Topic Leader of the Male Infertility Group for the WHO Infertility Guidelines.

· Peter Humaidan ·

Professor Peter Humaidan is a specialist in reproductive endocrinology, professor at The Fertility Clinic Skive Regional Hospital, Aarhus University, Denmark and Honorary professor at Odense University, Denmark. During his scientific work he has primarily focused on developing individualized treatment protocols for the infertile patient. His doctoral thesis (DMSc) explored the role of LH during the follicular and luteal phases in controlled ovarian stimulation. His main fields of interest are triggering of ovulation with GnRH agonist, role of LH during the follicular and luteal phases, role of the female genital tract microbiota for reproductive outcomes, OHSS prevention, and role of sperm DNA fragmentation for spontaneous and assisted reproduction. He is the founder of the international society “The Copenhagen GnRHa Triggering Workshop Group” who introduced the GnRHa trigger in modern IVF, changing trigger policies worldwide. He is co-founder of the POSEIDON group which suggested a new stratification of the poor responder patient, and a past board member of the ESHRE SIG Endocrinology Group. Finally, he is also co-founder of the APHRODITE group which suggested a new classification of the infertile male into five sub-groups who might benefit from medical treatment in terms of spermatogenesis. He is in the Elsevier, Stanford global list of 2% top scientists, and he authored and co-authored 270 + articles (H-index 70, Google Scholar) in international peer reviewed journals as well as chapters in textbooks and the Danish guidelines for OHSS prevention. Peter Humaidan has a wide international scientific network and is frequently invited as a speaker at international conferences.

· Kevin McEleny ·

Mr Kevin McEleny is a Consultant Urologist working both in Newcastle and at the Queen Elizabeth Hospital in Gateshead since 2009.

He is also Consultant Andrologist and Clinical Lead for the male factor clinic at the Newcastle Fertility Centre, located at the International Centre for Life, Times Square, Newcastle upon Tyne.

After completing his medical training and PhD at University College, Dublin, he continued his urological training in the Northern Region prior to his consultant appointment.

His main clinical interests include treating and diagnosing men with fertility problems. He organised and delivers the supra-regional Male Fertility service.

His research interests are in the field of male fertility and he is actively involved in male fertility training nationally.

· Paula Andrea Navarro ·

Associate Professor at FMRP-USP (Human Reproduction Sector, Department of Gynecology and Obstetrics), President of the Scientific Integrity and Good Practices in Research Committee at FMRP-USP, Director of the Assisted Reproduction Laboratory, Deputy Coordinator of the Human Reproduction Center , Coordinator of the Postgraduate Program in Gynecology and Obstetrics at FMRP-USP, President of the Brazilian Society of Human Reproduction (SBRH, biennium 2023 to 2025), Member of the Technical Chamber of Assisted Reproduction of the Federal Council of Medicine and Member of the National Commission Specialist (CNE) of Assisted Reproduction of the Brazilian Federation of Gynecology and Obstetrics (FEBRASGO). Researcher at the National Institute of Sciences and Technology/CNPq – Hormones and Women’s Health, Ad Hoc consultant for FAPESP, CNPq and CAPES. Chief Editor of the Human Reproduction Archives, Associate Editor of Reproductive Sciences and the Brazilian Journal of Ginecology and Obstetrics, Member of the Editorial Board of the Journal of Assisted Reproduction and Genetics and Ad Hoc reviewer for several high-impact scientific journals. Graduated in Medicine from the Faculty of Medicine of Ribeirão Preto at the University of São Paulo (FMRP-USP; 1995), medical residency in Gynecology and Obstetrics at the Hospital das Clínicas de Ribeirão Preto (HCRP-USP; 1999); master’s degree (2000), Research Fellow in Reproductive Endocrinology and Infertility, Women and Infants Hospital, Brown University and Laboratory for Reproductive Medicine, Marine Biological Laboratory (2001-2002) and PhD (2003) in Health Sciences, Gynecology and Obstetrics, FMRP -USP. Post-doctorate at New York University (2016-2017). His main research interests include: Understanding the etiopathogenic mechanisms of endometriosis-related infertility and other infertility factors; Improving the efficiency of assisted reproduction techniques; Evaluate the efficiency and safety of new strategies (adds on) in assisted reproduction procedures; Improvement of fertility preservation strategies, especially oocyte freezing; Improving access to infertility treatment

· Amina Oumeziane ·

Dr Oumeziane has a Medical Degree from Medicine’s Faculty, Algiers in 1989 and Post Graduate Degree-Specialty in gynecology obstetrics from medicine’s faculty, Algiers in 1994.
Completed her training in reproductive medicine at Cochin hospital Assistance Publique Hôpitaux , Paris.
In 2000, received Academic Diploma of Investigation and Management of Infertility from Medicine’s Faculty Rene Descartes Paris, France in 2007 and Diploma in Basic of Reproductive Medicine and Embryology from International School of Medicine Kiel, Munich in 2012.
Head of Tiziri ivf center in Algiers since 2004.
Founder of of subspeciality certificate in infertility in 2019.
Amina Oumeziane is the founder of the Algerian Society of Reproductive Medicine (SAMERE), served as its First president from 2013 to 2016 and Scientific Director from 2016-until now.

Member of the American Society of Reproductive Medicine (ASRM) and European Society of Human reproduction and Embryology (ESHRE), Reviewer in global reproductive health IFFS journal, RBMO and MEFS journals Amina’s major interest areas: Luteal phase, Agonist triggering, Frozen strategy, poor responders .

· Emre Pabuçcu ·

Emre Göksan Pabuçcu was born in Ankara in 1981. After graduating from TED Ankara Private High School, he started his medical education in Ankara University Faculty of Medicine. He completed his residency program in the Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine. He has been working at Ufuk University, Department of Obstetrics and Gynecology since 2013 where he received his Associated Professorship in 2017. He has worked at Houston Fertility Specialists Clinic and Texas Woman’s Hospital, Texas (2016) as an observer in the field of preimplantation genetic testing and minimal invasive surgery. He has also been working at Centrum Clinic Private IVF Center, Ankara/Turkey since 2012. He is actively interested in Reproductive Endocrinology and Reproductive Endoscopic procedures.  He is a former board member of International Society of Gynecologic Endoscopy (ISGE). Dr. Pabuçcu is currently a reviewer of several local and international journals about Reproductive Medicine, Endocrinology and Endoscopy. He has published more than 70 papers in peer reviewed journals. 

· Valerio Pisaturo ·

Valerio Pisaturo is a senior clinical embryologist with a Master’s degree in Reproductive Biology and specialization in Clinical Genetics. He is currently the Laboratory Director of the IVF Center at Policlinico Umberto I Hospital in Rome, Italy. Additionally, he holds the position of Adjunct Professor of Clinical Embryology and Genetics and serves as President of the Italian Society of Embryology, Reproduction, and Research (SIERR).

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