LIVE WEBINAR SERIES

Key components in the management of Central Precocious Puberty (CPP)

1st Webinar - 29 September 2023
2nd Webinar - 20 October 2023
3rd Webinar - 9 November 2023

WATCH THE RECORDED WEBINARS

Overview

CPP is a recognizable disorder which, with knowledge, skill and experience, can be managed effectively. The webinar series will inform pediatricians and pediatric endocrinologists how to recognise patients with CPP, and how to identify CPP amongst the wide variations of pubertal development (Bräuner, 2020). Once identified, does the patient with CPP need urgent therapy or a more conservative approach of careful observation? Key aspects of the child with rapidly advancing CPP will be clearly explained and demonstrated. The timing and initiation of GnRHa therapy will be discussed, with presentation of evidence comparing 6-monthly with 3-monthly and monthly administration. The three webinars will be live-streamed, with opportunities for the audience to ask questions and to interact with the Chair and presenters. After each live-stream, a recording of the webinar will be posted online and will be available globally as a free, open-access resource on the MedEA e-learning platform for up to a year after launch.

Learning Objectives

After attending the live webinars participants will be able to:

Target Audience

Pediatricians, endocrinologists and clinicians involved in growth management.

Language

The official language of this live educational activity will be English. Simultaneous translation into Spanish will be provided.

Continuing Medical Education
(CME)

The Awareness of CPP within the range of variations of growth and puberty in pediatric endocrine practice, Milan, Italy, 29/09/2023-29/09/2023 has been accredited by the European Accreditation

Council for Continuing Medical Education (EACCME®) with 1 European CME credits (ECMEC®s). Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.

Through an agreement between the Union Européenne des Médecins Spécialistes and the American Medical Association, physicians may convert EACCME® credits to an equivalent number of AMA PRA Category 1 CreditsTM. Information on the process to convert EACCME® credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities.

Live educational activities, occurring outside of Canada, recognised by the UEMS-EACCME® for ECMEC®s are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of the Royal College of Physicians and Surgeons of Canada.

UEMS EACCME©

The content of the “Awareness of CPP within the range of variations of growth and puberty in pediatric endocrine practice, Online 29th September 2023” has been certified by the CPD Certification Service as conforming to continuing professional development principles.

Key components in the management of Central Precocious Puberty (CPP)

Live Webinar Series
29 September 2023

20 October 2023

9 November 2023

Faculty

Martin O. Savage

Martin O. Savage

William Harvey Research Institute
Barts and the London School of Medicine and Dentistry
Queen Mary, University of London, UK
Sasha Howard

Sasha Howard

Centre for Endocrinology, Queen Mary University of London (QMUL)
Honorary Consultant in Paediatric Endocrinology, Barts Health NHS Trust
London, UK
Anders Juul

Anders Juul

Clinical Professor, University of Copenhagen
Head of Dept. of Growth and Reproduction, Rigshospitalet
Copenhagen, Denmark
Karen Klein

Karen Klein

Clinical Professor of Pediatrics
University of California San Diego
and Rady Children’s Hospital
San Diego, CA (USA)

International Committee

Jeff Bolton

Jeff Bolton

Chair of Trustees
Child Growth Foundation
UK
Muhammad Yazid Jalaludin

Muhammad Yazid Jalaludin

Vice President of Malaysian Endocrine and Metabolic Society (MEMS)
Deputy Dean and Professor of Pediatrics
Faculty of Medicine, University Malaya Medical Centre (UMMC)
Kuala Lumpur, Malaysia
Maria E Craig

Maria E Craig

President the Asia Pacific Paediatric Endocrine Society (APPES)
Children’s Hospital
Professor of Paediatric Endocrinology
University of New South Wales & University of Sydney
Sydney, Australia
Mariacarolina Salerno

Mariacarolina Salerno

President of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP)
Professor of Paediatrics and Head of the Paediatric Endocrinology Unit
University of Naples "Federico II" Naples, Italy
María Isabel Hernández C.

María Isabel Hernández C.

Coordinator of the Continuing Education Committee of the Latin American Society of Pediatric Endocrinology (SLEP)
Pediatric Endocrinologist and Assistant Professor
Department of Neurological Sciences
Institute of Neurosurgery Asenjo
Faculty of Medicine
University of Chile
Santiago, Chile
Raúl Calzada León

Raúl Calzada León

President of the Latin-American Society of Pediatric Endocrinology (SLEP)
Head of the Endocrinology Service National Institute of Pediatrics
Mexico City, Mexico
Ana Elena Chiesa

Ana Elena Chiesa

Coordinator of the International Relations Commission
Latin American Society of Pediatric Endocrinology (SLEP)
Pediatric Endocrinologist
Department of Pediatrics
R. Gutiérrez Children's Hospital
Buenos Aires, Argentina
Tabitha Randell

Tabitha Randell

Chair of the British Society for Paediatric Endocrinology and Diabetes (BSPED)
Consultant in Paediatric Endocrinology and Diabetes
Nottingham Children’s Hospital Nottingham, UK

Partnerships

Agenda

AGENDA

1st Webinar - 29 September 2023
2nd Webinar - 20 October 2023
3rd Webinar - 9 November 2023
Awareness of CPP within the range of variations of growth and puberty in pediatric endocrine practice
 
from 14.00 to 15.00 CEST

14.00–14.05 Pre-webinar survey - Participants

14.05–14.13 Introduction and aim of webinar - Chair: M.O. Savage (UK)

14.13–14.38 Awareness of CPP within the range of variations of growth and puberty in pediatric endocrine practice - Presenter: Sasha Howard (UK)

14.38–14.50 Panel discussion - Chair/Presenter/Participants

14.50–14.55 Post-webinar survey - Participants

14.55–15.00 Closing remarks - Chair: M.O. Savage (UK)

Early identification of CPP patients requiring GnRH analogue therapy
 
from 14.00 to 15.00 CEST

14.00–14.05 Pre-webinar survey - Participants

14.05–14.13 Introduction and aim of webinar - Chair: M.O. Savage (UK)

14.143–14.38 Early identification of CPP patients requiring GnRH analogue therapy - Presenter: Anders Juul (Denmark)

14.38–14.50 Panel discussion - Chair/Presenter/Participants

14.50–14.55 Post-webinar survey - Participants

14.55–15.00 Closing remarks - Chair: M.O. Savage (UK)

Choice and initiation of GnRHa therapy for CPP with emphasis on long-acting administration
 
from 17.00 to 18.00 CET

17.00–17.05 Pre-webinar survey - Participants

17.05–17.13 Introduction and aim of webinar - Chair: M.O. Savage (UK)

17.13–17.38 Choice and initiation of GnRHa therapy for CPP with emphasis on long-acting administration - Presenter: Karen Klein (USA)

17.38–17.50 Panel discussion - Chair/Presenter/Participants

17.50–17.55 Post-webinar survey - Participants

17.55–18.00 Closing remarks - Chair: M.O. Savage (UK)

Save the Date

Download

· Martin O. Savage ·

Martin Savage is Emeritus Professor of Paediatric Endocrinology at William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary, University of London. He was head of the Paediatric Endocrine Unit at Barts and the London School of Medicine from 1982 to 2007. He has interests in growth disorders, specifically those with abnormalities in the GH-IGF-1 axis and in phenotype-genotype relationships of GH-IGF-1 axis defects, notably GH resistance. He published the first human case of an IGF-1 gene defect in the New England Journal of Medicine in 1996.  His other interests are Cushing’s syndrome and growth in chronic inflammatory diseases. He was General Secretary of the European Society for Paediatric Endocrinology (ESPE) from 1997 to 2004. He has lectured in 60 countries and has published 482 original articles, reviews, textbook chapters and books. In 2007, he was awarded the ESPE Andrea Prader Prize for contributions to paediatric endocrinology and in 2018 he received a Visionary Award from the American Human Growth Foundation. In 2022, he received a Research Excellence Award from the Dr Sulaiman Al Habib Medical Journal in Riyadh, and the British Society of Paediatric Endocrinology & Diabetes James M. Tanner Lifetime Achievement Award. He continues to lecture nationally and internationally.

· Sasha Howard ·

Sasha Howard is a Wellcome Trust Clinical Research Career Development Fellow and Senior Lecturer at the Centre for Endocrinology, Queen Mary University of London (QMUL) and Honorary Consultant in Paediatric Endocrinology at Barts Health NHS Trust. Dr Howard’s research is focused on optimising the diagnosis and management of patients with pubertal disorders. Her research investigates the genetic basis of pubertal timing, using next-generation sequencing, comparative transcriptomic and epigenetic investigative approaches to identify novel genetic variants underlying precocious, delayed and disordered puberty. Dr Howard is member of the NIHR / BSPED Clinical Studies Group, the SoE UK Andrology network, the ESPE 2023 POC and Paediatric and Adolescent Gynaecology Working Group, and Co-PI of the Barts Pituitary Centre.

· Anders Juul ·

Anders Juul is clinical professor at the university of Copenhagen, and head of department of growth and reproduction at Rigshospitalet, Copenhagen, Denmark. He is trained as paediatric endocrinologist and EAA-certified andrologist. He is leader of research center EDMaRC (Endocrine Disruption of Male Reproduction and Child Health). His research interests include growth and pubertal disorders as well as genetic, epigenetic and environmental influences on gonadal and adrenal function throughout life. He has published more than 500 scientific papers (H index 80, web of science) and supervised more than 35 PhD students (hereof 29 completed), and 3 doctoral theses. In 2015 he received the prestigious ESPE Research Award. He initiated the Northeuropean SGA study (NESGAS), and acts as PI in several clinical studies including GH trials in children and adults.

· Karen Klein ·

Karen Oerter Klein is a Clinical Professor of Pediatrics at the University of California, San Diego, and Rady Children’s Hospital. She completed her medical school and Pediatric Residency at Pennsylvania State University College of Medicine. She did her pediatric endocrinology fellowship training at the National Institutes of Health (NIH). During her fellowship, she developed a bioassay for estradiol, which opened the door to research in areas of childhood growth and pubertal development, and have been the focus of her research since that time. Her primary research interests include: disorders of puberty and Turner Syndrome. She was part of the clinical trials for the newer GnRHa, and the international consensus group for the 2017 and upcoming 2024 guidelines in the care of girls and women with Turner Syndrome, and is director of the multidisciplinary clinic for Turner Syndrome at Rady Children’s Hospital. She also enjoys teaching medical students, residents, and fellows in all areas of general endocrinology and research, and serves as a mentor for some of her junior colleagues and the pediatric endocrine fellows at UCSD.

· Jeff Bolton ·

A BSc (Hons) and MBA graduate from Welsh universities, Jeff joined the pharmaceutical industry in 1990. Jeff first worked for Janssen-Cilag, where he performed a number of commercial and marketing management roles.

Jeff joined Pfizer in 2002 as Senior Brand Manager in the Endocrinology Team and transitioned into a European marketing role in 2006. Jeff became European Brand Director in 2010. Jeff left Pfizer in 2016 to start his own consultancy company, JRB Consultancy Services Ltd.

Jeff has been involved with growth conditions for over 20 years, and has won numerous awards, both national and international, for his role in developing campaigns and support information and materials for families affected by growth conditions. Jeff was the European lead for the development of the first growth prediction tool, iGRO, which was sponsored by Pfizer, and has since been rolled out in more than 25 countries.

Jeff has been a trustee of the Child Growth Foundation for over two years and became their Chair in 2022.

· Muhammad Yazid Jalaludin ·

Professor Dr Muhammad Yazid Jalaludin is The Deputy Dean (Undergraduate Studies) at the Faculty of Medicine, University Malaya. He is a Professor of Paediatrics at the Faculty of Medicine, Universiti Malaya and a practicing Senior Consultant Paediatrician and Senior Consultant Paediatric Endocrinologist at the University Malaya Medical Centre (UMMC). He completed his fellowship in Pediatric Endocrinology and Diabetes at Children’s Hospital of Philadelphia (CHOP), USA after obtaining his MBBS and Masters in Paediatrics, both from University Malaya. He is currently the Chairman of the Malaysian Paediatric Endocrinology and Diabetes Group (MPEDG), Vice President of the Malaysian Endocrine and Metabolic Society (MEMS 2022-2024), executive council member of the Malaysian Paediatric Association (MPA 2021-2023) and elected council member of Asia Pacific Paediatric Endocrine Society (APPES 2022-2024). Prof Jalaludin main research interest is in obesity and type 2 diabetes mellitus, growth (nutrition) and vitamin D in children. He holds many national and international research grants and acts as Scientific Advisor for many multi-centre international researches for type 2 diabetes and obesity in children. His work has been published in various academic journals including in the New England Journal of Medicine (NEJM).

· Maria E. Craig ·

Maria is a Paediatric Endocrinologist at the Children’s Hospital Westmead & St George Hospital in Sydney, Australia; Professor of Paediatric Endocrinology, University of New South Wales & University of Sydney, Medical Director, Australasian Diabetes Data Network (ADDN) and President the Asia Pacific Paediatric Endocrine Society (APPES). Her major research focus is childhood diabetes, including etiology, screening, prevention, epidemiology, evidence-based care and complications. She was editor-in chief of the International Society for Pediatric and Adolescent Diabetes (ISPAD) 2022 Clinical Care Guidelines.

· Mariacarolina Salerno ·

Mariacarolina Salerno is Professor of Paediatrics and Head of the Paediatric Endocrinology Unit at the  University of Naples “Federico II”, Italy.

Prof. Salerno  is the President of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP) and of SIEDP  summer/winter School.

She leads the Regional Center for Congenital Hypothyroidism screening follow- and is the paediatric HPC of the University Hospital Federico II for the European Network for Rare endocrine diseases (ENDO-ERN).

She is the past-director of the Pediatric Nursing School of the University of Naples “Federico II.

Prof. Salerno research interests include clinical research on thyroid disorders, short stature and growth hormone deficiency, adrenal insufficiency, autoimmune polyglandular diseases and cardio-metabolic alterations in paediatric endocrine diseases. She has authored more than 200 peer-reviewed papers. 

Prof. Salerno is Editor of the Journal of Endocrinological Investigation and Associated Editor of Hormone Research in Paediatrics. She has published more than 200  original articles, reviews, textbook chapters.

· Maria Isabel Hernández C. ·

Professor Dr María Isabel Hernández is Pediatric Endocrinologist and Professor of Pediatric Endocrinology at the Department of Neurological Science, Institute of Neurosurgery Asenjo and Institute of Maternal and Child Research, Faculty of Medicine, University of Chile. Coordinator of the Continuing Education Committee the Latin American Society of Pediatric Endocrinology and Chilean Society of Endocrinology and Diabetes.

Prof. Hernández´s main research interest is pituitary disease and special focus in pituitary tumors and follow up of pediatric patients after brain tumors treatment. She leads the Pediatric endocrinology unit of pituitary disease in the Institute of Neurosurgery in Chile, which is a referral center for pituitary disease in the country.

· Raúl Calzada León ·

Raúl Calzada León has been Chief of the Pediatric Endocrinology Service in the National Institute of Pediatrics, Mexico, since 1993. He was former President of the Mexican Society of Nutrition and Endocrinology and of the Mexican Society of Pediatric Endocrinology and is now the current President of the Latin-American Society of Pediatric Endocrinology. As well as clinical practice, Professor Calzada León is an active teacher and lecturer in endocrinology, pediatric endocrinology and clinical biochemistry at the National and Autonomous University of Mexico and the Medicine School at the National Polytechnic Institute of Mexico and advises nationally on Mexican health standards. He is a member of numerous national, regional and international societies for Endocrinology and Pediatrics. Professor Calzada León has published widely on many aspects of pediatric endocrinology, particularly on research into growth hormone treatment, congenital hypothyroidism, precocious puberty and early β-cell damage in pediatric patients with obesity and diabetes. He has been a member of the editorial board of Pediatric Endocrinology Review.

· Ana Elena Chiesa ·

Ana Elena Chiesa is Coordinator of the International Relations Commission of the Latin American Society of Pediatric Endocrinology (SLEP), Researcher at the CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) and at the GCBA research council, Attending Physician at the Division of Endocrinology, HNRG and Neonatal Screening (NBS) Program Medical Coordinator at the FEI (Fundación de Endocrinologia Infantil) and at the Buenos Aires City Government, Argentina. Doctor Chiesa is interested in the basic and clinical aspects of the thyroid axis. Her work is focused on thyroid disease during the neonatal period, childhood and adolescence. She carries on her research in different aspects related to neonatal screening (NBS) of inapparent diseases at birth such as Congenital Hypothyroidism, Congenital Adrenal Hyperplasia, and Phenylketonuria among others, taking care of the follow-up of patients.

· Tabitha Randell ·

Dr Tabitha Randell is a Consultant in Paediatric Endocrinology and Diabetes based at Nottingham Children’s Hospital, UK. She has over 25 years’ experience of working in paediatric diabetes and endocrinology, 20 years as a consultant, undergoing her training in both the UK and Australia. She is the current chair of the British Society for Paediatric Endocrinology and Diabetes (BSPED), elected in 2019 and taking up the role in 2020 following a year’s shadowing. She previously chaired the BSPED Clinical Committee from 2016-2020 and was the BSPED’s inaugural Media Officer from 2008-2012.