International Workshop

Gonadotropin-independent Folliculogenesis:

LH – FSH adjustment to optimize ovarian response

27 September 2024
Modena, Italy

Continuing Medical Education (CME)

Overview

Folliculogenesis, the process of producing a fertilizable oocyte, has been explored and studied extensively in the past few decades. Although processes regulating the early stages of follicular development are key determinants to optimize oocyte yield, they are less explored and discussed. Therefore, there are no optimized and definitive therapies for overcoming the suboptimal ovarian response. This meeting is focused on factors/mechanisms affecting the early stages of folliculogenesis. These include the potential effects of follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex steroids, anti-Müllerian hormone (AMH), and intraovarian signaling pathways on the early stages of follicle development. Discussing the latest discoveries in this field may eventually lead to improvements in Medically Assisted Reproduction (MAR) treatment for patients with ovarian-related infertility.

Learning Objectives

After participating in this workshop and related activities, participants will be able to:

Target Audience

Clinicians working in MAR globally. As materials will be online for 12 months following the workshops, participants from other regions and different healthcare disciplines can view these activities.

Health care specialists working in ART and in infertility treatment development, particularly Academic scholars/researchers, clinicians, andrologists, embryologists, other scientists, managers, and specialist nurses who want to remain up-to-date about advanced techniques, scientific innovations, and best practices using evidence-based models of care delivery.

Accreditation

This programme will be submitted for CME accreditation from the European Accreditation Council for Continuing Medical Education (EACCME) and for Continuing Professional Development (CPD) credits.

Language

The official language of all our educational activities is English.

Venue

University of Modena e Reggio Emilia

Faculty of Medicine and Surgery

General Hospital of Modena

Meeting room Magna of the Educational Services Centre

Via del Pozzo, 71 – 41100 Modena, Italy

International Workshop
Gonadotropin-independent Folliculogenesis:

LH – FSH adjustment to optimize ovarian response

27 September 2024

Chairs

Livio Casarini

Livio Casarini

University of Modena and Reggio Emilia
Modena, Italy
Antonio La Marca

Antonio La Marca

University of Modena and Reggio Emilia
Modena, Italy

Faculty

Claus Y. Andersen

Claus Y. Andersen

Women and Reproduction University Hospital of Copenhagen
Copenhagen, Denmark
Leonilda Bilo

Leonilda Bilo

University Federico II
Naples, Italy
Livio Casarini

Livio Casarini

University of Modena and Reggio Emilia
Modena, Italy
Nathalie Di Clemente

Nathalie Di Clemente

Sorbonne Université INSERM
Centre de Recherche Saint-Antoine (CRSA)
Institut Hospitalo-Universitaire ICAN
Paris, France
Renato Fanchin

Renato Fanchin

University of Paris — XI
Antoine Béclère Hospital in Clamart
Clamart, France
Stine Gry Kristensen

Stine Gry Kristensen

Copenhagen University Hospital
Copenhagen, Denmark
Elena Labarta

Elena Labarta

IVI RMA Valencia
Valencia, Spain
Antonio La Marca

Antonio La Marca

University of Modena and Reggio Emilia
Modena, Italy
Daniele Santi

Daniele Santi

University of Modena and Reggio Emilia
Modena, Italy

Agenda

· Antonio La Marca ·

Antonio La Marca is Professor of Obstetrics and Gynecology at the Mother-Infant Department of the University of Modena and Reggio Emilia, Italy and he is the Medical Director of Clinica Eugin, Modena, Italy. He graduated in Medicine and Surgery at the University of Siena in 1996, specializing in Obstetrics and Gynaecology at the same institution in 2001. In 2006 he obtained a PhD, again at the University of Siena. He has been working at the Institute of Gynaecology and Obstetrics of the University Hospital of Modena since 2003. His clinical activity covers all the field of Reproductive Medicine and Surgery and has taken part in thousands of IVF cycles, laparoscopic and hysteroscopic surgical procedures. Present scientific interests include: ovarian reserve and pharmacological manipulation of ovarian activity. His most impactful articles concerned the physiological significance of AMH and AFC, their measurement and clinical utility. Moreover, he has published a long list of original articles dealing with the prediction of ovarian reserve and response in IVF and the personalization of ovarian stimulation protocols. He is author or coauthor of 128 articles published in peerreviewed journals and authored many 26 Antonio La Marca University of Modena and Reggio Emilia and Clinica Eugin Modena, Italy chapters in national and international textbooks. He has been an Invited speaker in more than 100 international congresses. He is involved in several phase three and four trials as Principal Investigator and is the recipient of many competitively assigned research funds. He is an active member of many national and international professional and scientific societies and a consultant for the Italian Ministry of Health for female fertility-related issues.

· Claus Yding Andersen ·

Claus Yding Andersen is Scientific Director of Laboratory of Reproductive Biology, University Hospital of Copenhagen, Denmark and Professor of Human Reproductive Physiology within the Faculty of Health and Medical Sciences at the University of Copenhagen.  He is educated as MSc (1979) and DMSc (1997).

Professor Andersen was a member of the team that introduced IVF to Denmark in the mid-1980s, is senior accredited ESHRE embryologist and have worked as a consultant in more 10 fertility clinics nationally and internationally. During the last fifteen years he has headed a national program of cryopreservation of human ovarian and testicular tissue, which is approved by the Danish Authorities. He is considered one of the pioneers in this field and continue to expand the indications for the use of ovarian tissue cryopreservation in different clinical settings.

Professor Andersen’s major research contributions have been in ovarian endocrinology, oocyte maturation, cryopreservation of gonadal tissue, human embryonic stem cells and development of new principles for ovarian stimulation including the introduction of the agonist trigger and novel approaches to luteal phase support.

He has published more than 300 peer-reviewed scientific papers plus 9 patents. He is a much-requested international lecturer and is currently giving 20-30 international lectures annually. His current H-index is 60 and has received almost 12.000 citations (Google Scholar).

He has served on the editorial board on five international journals and has reviewed papers for more than 25 international journals and six national research councils. His is currently chief editor on the Reproduction section in Frontiers in Endocrinology.

· Martin O. Savage ·

Martin Savage is Emeritus Professor of Paediatric Endocrinology at William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary, University of London. He was head of the Paediatric Endocrine Unit at Barts and the London School of Medicine from 1982 to 2007. He has interests in growth disorders, specifically those with abnormalities in the GH-IGF-1 axis and in phenotype-genotype relationships of GH-IGF-1 axis defects, notably GH resistance. He published the first human case of an IGF-1 gene defect in the New England Journal of Medicine in 1996.  His other interests are Cushing’s syndrome and growth in chronic inflammatory diseases. He was General Secretary of the European Society for Paediatric Endocrinology (ESPE) from 1997 to 2004. He has lectured in 61 countries and has published 472 original articles, reviews, textbook chapters and books. In 2007, he was awarded the ESPE Andrea Prader Prize for contributions to paediatric endocrinology and in 2018 he received a Visionary Award from the American Human Growth Foundation. In 2022, he received a Research Excellence Award from the Dr Sulaiman Al Habib Medical Journal in Riyadh, and the British Society of Paediatric Endocrinology & Diabetes James M. Tanner Lifetime Achievement Award. He continues to lecture nationally and internationally.