Thyroid hormones maintain metabolic homeostasis, so thyroid dysfunction impacts multiple body systems, which in turn influence each other. This webinar explores the effects of hypothyroidism on liver function, kidney function and cardiovascular function and how imbalance in each of these areas impacts each of the others, collectively contributing, with insulin resistance, to metabolic dysfunction. The liver and the thyroid are intimately linked [Ritter, 2020; Hidalgo-Álvarez, 2023; Mendoza, 2021, [Piantanida, 2020]. Patients with hypothyroidism have suboptimal cholesterol and lipid levels [Ritter, 2020] and are at higher risk of developing Non-Alcoholic Fatty Liver Disease (NAFLD)/Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) than those who are euthyroid [Notariza, 2019; Targher, 2024]. Hepatic dysfunction associated with hypothyroidism is usually reverted by normalizing thyroid status, but overlapping symptomatology between liver dysfunction and severe hypothyroidism may delay diagnosis and treatment of hypothyroidism [Yorke, 2024]. Hypothyroidism and hyperthyroidism both affect renal function by direct renal effects as well as hemodynamic, metabolic and cardiovascular effects [Iglesias, 2017]. This relationship is bidirectional. Most of the renal manifestations caused by thyroid dysfunction are reversible on treatment of the thyroid issues [Iglesias, 2017], although relevant clinical studies are scarce [Naguib, 2023]. Subclinical hypothyroidism in chronic and end-stage kidney disease patients increases their risk of cardiovascular disease morbidity and mortality above that of the general population [Iglesias, 2017; Spahia, 2023].Thyroid hormones, kidney function and liver function are intertwined – this webinar aims to explore and explain these interconnections.