This webinar series explores current CPP occurrence and incidence patterns, including the potential role of obesity, and examines how treatment can support children with complex medical conditions that include CPP. Although each webinar addresses a specific topic, the presentations are interconnected and designed to provide specialist clinicians with practical guidance for diagnosing and managing CPP. Complex case studies will highlight diagnostic challenges, treatments involving several endocrine medications and how newer formulations may help the patient and their families. GnRH agonist (GnRHa) therapy remains an effective and well-tolerated treatment for CPP, suppressing sex hormone production and slowing skeletal maturation. The introduction of longer-acting formulations has expanded opportunities for individualized treatment while reducing the burden of frequent injections. These regimens may improve adherence, increase patient satisfaction and potentially reduce healthcare costs. The webinar series addresses key educational gaps: distinguishing normal developmental variants from true precocious puberty, differentiating peripheral from CPP, managing syndromic forms of CPP, and managing cases in which CPP is secondary to other genetic disorders, including children with neurodevelopmental disabilities. This webinar series aims to tackle this demanding area with presentations of complex clinical cases to help widen knowledge and encourage best practice.